How to take Retevmo
Retevmo is taken by itself and not in combination with additional cancer therapies
Common questions about how to take Retevmo
Take Retevmo orally twice a day, with each dose separated by 12 hours, unless your doctor tells you otherwise.
Take Retevmo exactly as your doctor tells you. Your doctor may change your dose, if needed. Do not change your dose or stop taking Retevmo without talking to your doctor.
*If you take:
- a proton-pump inhibitor (PPIs such as dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole sodium, and rabeprazole), take Retevmo with food
- an antacid that contains aluminum, magnesium, calcium, simethicone, or buffered medicines, take Retevmo 2 hours before or 2 hours after taking the antacid
- an H2 blocker (such as famotidine, nizatidine, and cimetidine), take Retevmo 2 hours before or 10 hours after taking the H2 blocker
Do not take a missed dose of Retevmo unless it is more than 6 hours until your next scheduled dose.
If you get sick after taking a dose, do not take an extra dose, and take your next dose at your regular time. In the event that you take too much Retevmo, call your doctor or go to the nearest hospital emergency room right away.
If you have questions about Retevmo or need more information on how to take it, you should talk to your doctor. You can also call the Lilly Oncology Support Center at 1-866-472-8663 or sign up for the Retevmo Ongoing Support Program.
Some possible side effects with Retevmo
- Retevmo may cause serious side effects, including liver problems, high blood pressure (hypertension), heart rhythm changes (QT prolongation), bleeding problems, allergic reactions, risk of wound healing problems, and risk to unborn babies
- The most common side effects include increased levels of liver enzymes; increased blood sugar levels; decrease in white blood cell count; decreased protein levels (albumin) in the blood; decreased levels of calcium in the blood; dry mouth; diarrhea; increased creatinine (kidney function test); high blood pressure; tiredness; swelling of your arms, legs, hands, and feet (peripheral edema); decrease in platelet count; increased cholesterol levels; rash; decreased levels of salt (sodium) in the blood; and constipation. Retevmo may affect fertility in females and males, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you
In a clinical trial, 5% of people stopped taking Retevmo due to side effects
- Rare adverse reactions resulting in permanently stopping Retevmo included increased liver enzymes, serious infection, allergic reactions, fatigue, and bleeding problems
- Side effects requiring dosage interruption in more than 2% of patients included increased liver enzymes, high blood pressure, diarrhea, fever, and heart rhythm changes
- Side effects requiring lowered dose in more than 2% of patients included increased liver enzymes, heart rhythm changes, and fatigue
These are not all of the possible side effects of Retevmo. If you experience side effects while on treatment, it is important that you speak with your doctor or pharmacist. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088. You may also report side effects to Eli Lilly and Company at 1-800-LillyRx (1‑800‑545‑5979).
You should avoid taking St. John's wort, proton-pump inhibitors (PPIs such as dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole sodium, rabeprazole), H2 blockers (such as famotidine, nizatidine, and cimetidine), and antacids that contain aluminum, magnesium, calcium, simethicone, or buffered medicines during treatment with Retevmo.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Certain other medicines may affect how Retevmo works. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
If you're taking or about to start taking Retevmo, learn more about Retevmo Savings and Support.
Governmental beneficiaries excluded, terms and conditions apply.